Red light therapy clinical research

Red light therapy is supported by thousands of medical and clinical studies, which have shown overwhelmingly positive results. Read here some of the studies on which the science pages on our website are based.

Red light therapy:

Effect of wavelength and beamwidth on penetration in light-tissue interaction using computational methods
https://link.springer.com/article/10.1007/s10103-017-2317-4

NASA & Red Light Therapy. Source: NASA/Marshall Space Flight Center https://pubmed.ncbi.nlm.nih.gov/11776448/https://www.sciencedaily.com/releases/2000/12/001219195848.htm

Primary and secondary modes of action of visible to near IR radiation on cells
https://pubmed.ncbi.nlm.nih.gov/10365442/

Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 hours
https://pubmed.ncbi.nlm.nih.gov/25443662/

Biphasic dose response to light light therapy
https://pubmed.ncbi.nlm.nih.gov/20011653/

Advantages:

Inflammation: Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523874/

Research on Phototherapy, Light Therapy and Photobiomodulation for Healing – Alternative Therapy…
https://pubmed.ncbi.nlm.nih.gov/30477871/

Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells: in vitro study
https://pubmed.ncbi.nlm.nih.gov/29116611/

The use of low-level laser therapy (LLLT) for musculoskeletal pain
https://pubmed.ncbi.nlm.nih.gov/26858986/

Skin: The efficacy of red and near infrared light treatment on patient satisfaction, reduction of fine lines, wrinkles, skin roughness and increase in intradermal collagen density.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926176/

Low level laser (light) therapy (LLLT) in the skin: stimulating, healing, restorative
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

Combination of 830-nm and 633-nm light-emitting diode phototherapy shows promise in the treatment of recalcitrant psoriasis: preliminary findings
https://pubmed.ncbi.nlm.nih.gov/19764893/


Collagen & Skin Rejuvenation:
Effects of Radio Frequency, Electroacupuncture and Low Level Laser Therapy on Wrinkles and Moisture in Forehead, Eyes and Cheek
https://pubmed.ncbi.nlm.nih.gov/28265160/

Effectiveness of red and near infrared light treatment on patient satisfaction, reduction of fine lines, wrinkles, skin roughness and increase in intradermal collagen density
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926176/

Effects of low-level radiofrequency, electroacupuncture, and laser therapy on forehead, eye, and cheek wrinkles and moisture
https://pubmed.ncbi.nlm.nih.gov/28265160/

Low level laser (light) therapy (LLLT) in the skin: stimulating, healing, restorative
https://pubmed.ncbi.nlm.nih.gov/24049929/

Effect of low-level laser therapy on type I and III collagen and inflammatory cells in rats with induced third-degree burns
https://pubmed.ncbi.nlm.nih.gov/23677436/

Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a study
https://pubmed.ncbi.nlm.nih.gov/19587693/

Skin photorejuvenation effects of light-emitting diodes (LEDs): a comparative study of yellow and red LEDs in vitro and in vivo
https://pubmed.ncbi.nlm.nih.gov/27663159/

Combined treatment with low-level laser and rhBMP-2 promotes differentiation and mineralization of osteoblastic cells under hypoxic stress
https://pubmed.ncbi.nlm.nih.gov/30603597/

Continuous irradiation with 633nm light emitting diode has anti-aging effect on human skin cells
https://pubmed.ncbi.nlm.nih.gov/25503577/

A controlled study to determine the efficacy of red and near infrared light treatment on patient satisfaction, reduction of fine lines, wrinkles, skin roughness and increase in intradermal collagen density
https://pubmed.ncbi.nlm.nih.gov/24286286/

Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blind study
https://pubmed.ncbi.nlm.nih.gov/19587693/

sleep

Effects of lights of different color temperatures on the nighttime changes in core temperature and melatonin in humans.
http://europepmc.org/article/med/8979406

Sleep disturbances in the circadian rhythm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523094/

Suprachiasmatic nucleus in sleep-wake regulation
https://pubmed.ncbi.nlm.nih.gov/18032104/

Pain

Effects of low-level laser therapy (LLLT) on the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to recovery after exercise.
https://pubmed.ncbi.nlm.nih.gov/20436237/

Low-level laser therapy for osteoarthritis and rheumatoid arthritis: a meta-analysis
https://pubmed.ncbi.nlm.nih.gov/10955339/

Sport

When is the best time to use phototherapy in conjunction with a strength training program? Phototherapy in combination with strength training:
https://pubmed.ncbi.nlm.nih.gov/27371449/

Effects of low-level (808 nm) laser therapy on physical strength training in humans
https://pubmed.ncbi.nlm.nih.gov/21086010/

Infrared LED radiation applied during intense treadmill training improves maximum exercise tolerance in postmenopausal women: a 6-month longitudinal study
https://pubmed.ncbi.nlm.nih.gov/22382875/

Phototherapy during treadmill training improves quadriceps performance in postmenopausal women
https://pubmed.ncbi.nlm.nih.gov/23895414/

Phototherapy effect on muscle activity of regular physical activity practitioners
https://pubmed.ncbi.nlm.nih.gov/24288083/

Photobiomodulation Therapy (PBMT) and/or Cryotherapy in Skeletal Muscle Recovery, Which Is Better? A randomized, double-blind, placebo-controlled clinical trial
https://pubmed.ncbi.nlm.nih.gov/27624781/

Hair

Low-level laser therapy as a treatment for androgenetic alopecia
https://onlinelibrary.wiley.com/doi/abs/10.1002/lsm.22512

Comparative effectiveness of low-level laser therapy for androgenic alopecia in adults: a systems review and meta-analysis of randomized controlled trials
https://pubmed.ncbi.nlm.nih.gov/30706177/

Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis
https://pubmed.ncbi.nlm.nih.gov/29797431/

Low-level laser therapy as a treatment for androgenetic alopecia
https://pubmed.ncbi.nlm.nih.gov/27114071/

Low-level laser therapy as a treatment for androgenetic alopecia
https://pubmed.ncbi.nlm.nih.gov/29270707/

Efficacy and safety of a low-level laser device in the treatment of hair loss in men and women
https://pubmed.ncbi.nlm.nih.gov/24474647/

Efficacy and safety of a low-level laser device in the treatment of hair loss in men and women
https://pubmed.ncbi.nlm.nih.gov/25124964/

Different Wavelengths of LED Light Regulate the Proliferation of Human Skin Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways
https://pubmed.ncbi.nlm.nih.gov/29200764/

Hormones & Testosterone

thyroid
Low-level laser in the treatment of patients with hypothyroidism caused by chronic autoimmune thyroiditis
https://pubmed.ncbi.nlm.nih.gov/22718472/

Assessing the Effects of Low-Level Laser Therapy on Thyroid Vascularization in Patients with Autoimmune Hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/23316383/

Low-level laser therapy in chronic autoimmune thyroiditis
https://pubmed.ncbi.nlm.nih.gov/20662037/

Eyes

Low-level light therapy of the eye and brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/

Brain

Photobiomodulation and the brain
https://pubmed.ncbi.nlm.nih.gov/28580093/

RLT of the eye and brain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/

Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans
https://pubmed.ncbi.nlm.nih.gov/23200785/

Improving Executive Function Using Transcranial Infrared Laser Stimulation
https://pubmed.ncbi.nlm.nih.gov/26017772/

RLT and Altzeimers
https://pubmed.ncbi.nlm.nih.gov/21116053/

RLT and Parkinsons
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140880

Infrared laser therapy for ischemic stroke: a new treatment strategy
https://pubmed.ncbi.nlm.nih.gov/17463313/

Fat loss

Influence of water-filtered infrared-A (wIRA) on reduction of local fat and body weight through exercise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/

Body contouring using 635nm low-level laser therapy
https://pubmed.ncbi.nlm.nih.gov/24049928/

Efficacy of low-level laser therapy for body contouring and fat reduction
https://pubmed.ncbi.nlm.nih.gov/20393809/